منابع مشابه
Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody.
Inhibition of tumor angiogenesis is a promising approach for cancer therapy. As an endothelial cell-specific receptor kinase expressed almost exclusively on the surface of vascular endothelium, Tie-2 has an important role in tumor angiogenesis. To explore the therapeutic potential of blocking Tie-2 receptor-interaction pathway, an adenoviral vector was used to deliver a recombinant single-chain...
متن کاملCancer-targeting gene therapy using tropism-modified adenovirus.
Gene therapy has the potential to provide highly selective, curative cancer treatments without inducing systemic toxicity. Adenoviral vectors have been extensively used for cancer gene therapy because of their relatively high efficacy of gene transfer. However, gene transduction to cancer cells is limited by the necessity of using adenoviral type 5 vectors. This is because these vectors have a ...
متن کاملRecent Progress in Strategies for Adenovirus Mediated Therapeutic Cell Targeting
Increasing numbers of therapeutic genes and cellular targets are available for gene therapy. Many clinical trials using virus-derived delivery systems are devoted to combat cancer, to correct single-gene malfunctions or to regenerate tissues. To develop gene delivery vectors with high effi ciency through target cell selectivity, in particular under in situ conditions, remains a major challenge....
متن کاملDevelopment of an immunotherapeutic adenovirus targeting hormone-independent prostate cancer
BACKGROUND To develop a targeting therapy for hormone-independent prostate cancer, we constructed and characterized conditionally replicating oncolytic adenovirus (Ad) equipped with mRFP (monomeric red fluorescence protein)/ttk (modified herpes simplex virus thymidine kinase). This construct was then further modified to express both mRFP/ttk and a soluble form of cytokine FLT3L (fms-related tyr...
متن کاملAdenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain.
The use of adenovirus (Ad) vectors for cancer gene therapy applications is currently limited by several factors, including broad Ad tropism associated with the widespread expression of coxsackievirus and adenovirus receptor (CAR) in normal human tissues, as well as limited levels of CAR in tumor cells. To target Ad to relevant cell types, we have proposed using soluble CAR (sCAR) ectodomain fus...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2000
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3301115